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Gut Microbiota-Controlled Tryptophan Metabolism Improves D-Gal/LPS-Induced Acute Liver Failure in C57BL/6 Mice Article

Zhipeng Zheng, Li Wu, Yuqiu Han, Jun Chen, Shuai Zhu, Yuanyuan Yao, Baohong Wang, Lanjuan Li

Engineering 2022, Volume 14, Issue 7,   Pages 134-146 doi: 10.1016/j.eng.2020.12.013

Abstract: As an endogenous aryl hydrocarbon receptor (AhR) ligand, Kyn has anti-inflammatory and immunosuppressive

Keywords： Gut microbiota     Antibiotic     Tryptophan     Kynurenine     Aryl hydrocarbon receptor     Acute liver failure    

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Hydrophilic modification of poly(aryl sulfone) membrane materials toward highly-efficient environmental

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 5,   Pages 614-633 doi: 10.1007/s11705-021-2115-1

Abstract: Poly(aryl sulfone) as a typical membrane material has been widely used due to excellent mechanical, chemicalHowever, the inherent hydrophobicity of poly(aryl sulfone) based membranes bears with the fouling issueon characterizations of hydrophilic membrane and diverse hydrophilic modification approaches of poly(arylto guide the future directions to develop novel technology to manipulate the hydrophilicity of poly(aryl

Keywords： poly(aryl sulfone)     membrane separations     modification     hydrophilicity     water treatment    

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Cobalt nitride enabled benzimidazoles production from furyl/aryl bio-alcohols and -nitroanilines without

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 1,   Pages 68-81 doi: 10.1007/s11705-022-2174-y

Abstract: Benzimidazole derivatives have wide-spectrum biological activities and pharmacological effects, but remain challenging to be produced from biomass feedstocks. Here, we report a green hydrogen transfer strategy for the efficient one-pot production of benzimidazoles from a wide range of bio-alcohols and o-nitroanilines enabled by cobalt nitride species on hierarchically porous and recyclable nitrogen-doped carbon catalysts (Co/CNx-T, T denotes the pyrolysis temperature) without using an external hydrogen source and base additive. Among the tested catalysts, Co/CNx-700 exhibited superior catalytic performance, furnishing 2-substituted benzimidazoles in 65%–92% yields. Detailed mechanistic studies manifest that the coordination between Co2+ and N with appropriate electronic state on the porous nitrogen-doped carbon having structural defects, as well as the remarkable synergetic effect of Co/N dual sites contribute to the pronounced activity of Co/CNx-700, while too high pyrolysis temperature may cause the breakage of the catalyst Co–N bond to lower down its activity. Also, it is revealed that the initial dehydrogenation of bio-alcohol and the subsequent cyclodehydrogenation are closely correlated with the hydrogenation of nitro groups. The catalytic hydrogen transfer-coupling protocol opens a new avenue for the synthesis of N-heterocyclic compounds from biomass.

Keywords： biomass conversion     furanic compounds     benzimidazoles     hydrogen transfer     bifunctional catalysis    

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Catalysis and deactivation of montmorillonite K10 in the aryl O -glycosylation of glycosyl trichloroacetoimidates

Xiaoliu LI, Xinhao YAN, Zhiwei LI, Hua CHEN, Pingzhu ZHANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 342-347 doi: 10.1007/s11705-009-0279-1

Abstract: The catalysis of montmorillonite K10 (MK10) for aryl -glycosylation of glycosyl trichloroacetimidates

Keywords： photoelectron spectroscopy     adsorption-desorption     glycosylation     deactivated     diffraction    

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The characteristics of Paleozoic marine hydrocarbon accumulation in China

Kang Yuzhu

Strategic Study of CAE 2010, Volume 12, Issue 5,   Pages 11-17

Abstract: A great breakthrough of Paleozoic marine hydrocarbon field was achieved in Shacan No. 2 well in 1982.Through deep research of many Paleozoic marine hydrocarbon fields, the author proposed Paleozoic marinehydrocarbon accumulation theory in 1992, which includes superposition composite basin accumulation,accumulation, multi-era and multi-type reservoir-seal assemblage, multi-accumulation model and that hydrocarbon

Keywords： Paleozoic era     marine hydrocarbon field     basin     uplift     depression     hydrocarbon distribution    

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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract: cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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exogenous degrader-enhanced bioremediation with low-dose persulfate oxidation for polycyclic aromatic hydrocarbon

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 11, doi: 10.1007/s11783-023-1733-x

Abstract: Polycyclic aromatic hydrocarbon (PAH)-contaminated soils are usually complex and characterized by a lack

Keywords： Bioaugmentation     Low-dose persulfate oxidation     Polycyclic aromatic hydrocarbon     Remediation    

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Potential and development of unconventional hydrocarbon resources in China

Hu Wenrui,Zhai Guangming,Li Jingming

Strategic Study of CAE 2010, Volume 12, Issue 5,   Pages 25-29

Abstract:

The situation of development and utilization of unconventional hydrocarbonresources in world and in China was summarized, difficulties in unconventional hydrocarbon resourcesdevelopment were analyzed and policies and proposals to speed up the development of unconventional hydrocarbon

Keywords： unconventional hydrocarbon     exploration and development     technology     potential     countermeasure    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound , , , , , , and were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B in VERO cells.

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitorsoutput, and consider the problems of signaling pathway redundancy and how the activation of different receptor

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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The potential and exploring progress of unconventional hydrocarbon resources in SINOPEC

Ma Yongsheng,Feng Jianhui,Mu Zehui,Zhao Peirong,Bao Shujing,Wang Feng

Strategic Study of CAE 2012, Volume 14, Issue 6,   Pages 22-30

Abstract:

The unconventional hydrocarbon resources are very abundant within theSince 2004, SINOPEC has started to pay attention to unconventional hydrocarbon resources and launchedRecently, unconventional hydrocarbon resources exploration of SINOPEC has obtained breakthrough and progressresources type” and “multi-stage” exploration and development form on unconventional hydrocarbon

Keywords： SINOPEC (China Petroleum & Chemical Corporation )     unconventional hydrocarbon     hydrocarbon resources    

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Application of light hydrocarbon analysis logging in Hailar Basin

Wu Changjin,Ma Changwei,Zhang Kecao

Strategic Study of CAE 2012, Volume 14, Issue 4,   Pages 49-57

Abstract: formation debris logging, geochemical logging to identify oil and gas, and evaluate reservoir, light hydrocarbonThis paper entails the principles and features of light hydrocarbon logging, and analyzes the results

Keywords： Hailar Basin     light hydrocarbon analysis     logging technology     oil and gas discovery     reservoir appraisal    

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Deepwater Hydrocarbon Exploration in China Seas: Yesterday, Today and Tomorrow

Zhi-gang Zhao,Hai-zhang Yang,Wu Tang,Shi-xiang Liu

Frontiers of Engineering Management 2016, Volume 3, Issue 4,   Pages 390-395 doi: 10.15302/J-FEM-2016059

Abstract: Deepwater area has been one of the hottest areas in the global hydrocarbon exploration.However, deepwater hydrocarbon exploration in China started late and mainly concentrated in the SouthThe future directions of deepwater hydrocarbon exploration mainly consist of five aspects: establishingThese understandings will help guiding the future deepwater hydrocarbon exploration in China Seas.

Keywords： deepwater hydrocarbon exploration     China Seas     South China Sea     Pearl River Mouth Basin     Qiongdongnan Basin    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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Title Author Date Type Operation

Gut Microbiota-Controlled Tryptophan Metabolism Improves D-Gal/LPS-Induced Acute Liver Failure in C57BL/6 Mice

Zhipeng Zheng, Li Wu, Yuqiu Han, Jun Chen, Shuai Zhu, Yuanyuan Yao, Baohong Wang, Lanjuan Li

Journal Article

Hydrophilic modification of poly(aryl sulfone) membrane materials toward highly-efficient environmental

Journal Article

Cobalt nitride enabled benzimidazoles production from furyl/aryl bio-alcohols and -nitroanilines without

Journal Article

Catalysis and deactivation of montmorillonite K10 in the aryl O -glycosylation of glycosyl trichloroacetoimidates

Xiaoliu LI, Xinhao YAN, Zhiwei LI, Hua CHEN, Pingzhu ZHANG,

Journal Article

The characteristics of Paleozoic marine hydrocarbon accumulation in China

Kang Yuzhu

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

exogenous degrader-enhanced bioremediation with low-dose persulfate oxidation for polycyclic aromatic hydrocarbon

Journal Article

Potential and development of unconventional hydrocarbon resources in China

Hu Wenrui,Zhai Guangming,Li Jingming

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

The potential and exploring progress of unconventional hydrocarbon resources in SINOPEC

Ma Yongsheng,Feng Jianhui,Mu Zehui,Zhao Peirong,Bao Shujing,Wang Feng

Journal Article

Application of light hydrocarbon analysis logging in Hailar Basin

Wu Changjin,Ma Changwei,Zhang Kecao

Journal Article

Deepwater Hydrocarbon Exploration in China Seas: Yesterday, Today and Tomorrow

Zhi-gang Zhao,Hai-zhang Yang,Wu Tang,Shi-xiang Liu

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article

microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor

Journal Article